Carbohydrate Synthesis & Peptide Synthesis

Synthesis, in general, refers to the combination of two or more things, whether material or abstract, to create something new; or, in a wider context, it also refers to the development of something. This concept, synthesis, is used frequently in chemistry and biochemistry. Check This Out..

Synthesis of Carbohydrates

Chemical synthesis is the term used in chemistry to describe a broad variety of processes. Chemical synthesis is crucial to many chemistry studies because it allows for the discovery of new compounds with novel physical or biological properties. It’s also necessary for drug development if new drugs are to be created.

Carbohydrate synthesis is one of the classifications of chemical synthesis, and it includes the development of a number of complex compounds such as oligosaccharide, glycan, sugar amino acid, glycopeptide, glycoconjugate, and so on.

Carbohydrate serves a variety of functions in living organisms, ranging from primary energy source to cell-cell interactions to cancer metastasis. As a result, carbohydrate plays an important role in a variety of biological processes. However, due to their structural structure, they are difficult to synthesise.

The difficulties of carbohydrate synthesis, according to a book titled Carbohydrate Chemistry, Biology, and Medical Applications, are as follows:

  1. a) Since all hydroxyl groups have similar properties, it’s difficult to differentiate the exact hydroxyl group at a given location from other hydroxyl groups.
  2. b) Glycosylation reactions are far more complex than other types of synthesis, and as a result, yields are often low.
  3. c) The most difficult problem is achieving the optimal glycosidic linkage in a stereoselective way.